Linking Brain Arousal States and Breathing

Where: Toronto Rehab – University Centre, Rm 12-157, 550 University Ave., Toronto, M5G 2A2

When: Tuesday, June 28th, 12PM-1PM

Speaker:          Gaspard Montandon, PhD

Affiliation:      Systems Neuroscience and Respiratory Physiology, Department of Medicine, University of Toronto

Abstract:         Breathing is an essential function generated by the brainstem and controlled by subcortical and cortical areas. During sleep, breathing is reduced and sleep-disordered breathing may occur. Similarly, patients who receive opioid analgesics enter a sedative state that contributes to respiratory depression. Here, we explored the link between reduced brain arousal states, such as sleep and sedation, and respiratory depression. By using various animal models and novel approaches to analyse cortical activity, we aim to explore the mechanisms linking brain arousal states and breathing.

Biography:      Dr. Montandon is a Parker B. Francis Fellow investigating the neural control of breathing. He completed his PhD in Quebec on the development of the neural control of breathing. In Toronto, Dr. Montandon investigates the neural circuits of breathing and brain arousal states and the impacts of sleep, anesthetics and opioid drugs on brain and respiratory functions. Dr. Montandon uses state-of-the-art neuroscience techniques, such as optogenetics, to probe neural circuits in animals and signal processing to understand cortical and respiratory activities in humans. His recent work aims to elucidate the mechanisms of opioid-induced respiratory depression using a translational approach spanning basic research and clinical studies.