Acute, Sub-acute and Chronic Therapeutic Strategies Post-Spinal Cord Injury

Where: Toronto Rehab – University Centre, Lecture Theater (basement), 550 University Ave., Toronto, M5G 2A2

When: Thursday, November 3rd, 12PM-1PM

Speaker:          Angelo ALL, M.D., MBA

Affiliation:      Departments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine; and Departments of Orthopedic Surgery and Biomedical Engineering, National University of Singapore

Abstract:        First, I would present experimental methods to generate a calibrated contusive SCI model and the monitoring of neuro-electrophysiological function. Second, I would present results on the effects of (i) acute hypothermia, (ii) sub-acute administration of conjugated polymers for drug delivery and (iii) chronic human stem cell replacement therapy post-contusive SCI with the expectation that these promising strategies will translate into future clinical studies.

Biography:      Dr. Angelo ALL, M.D., MBA, started his higher education in Pharmacy School, graduated from Medical School, continued his career as a surgery fellow and obtained a MBA degree from the Johns Hopkins University. Since 2000, his Biomedical and Neuro-Engineering research at the Johns Hopkins Medical Institute has shaped his career. Dr. ALL is an Assistant Professor at the Departments of Biomedical Engineering and Neurology, Division of Neuroscience and Neuroengineering, School of Medicine, Johns Hopkins University. He also holds a Faculty position of Assistant Professor at the Departments of Orthopedic Surgery and Biomedical Engineering as well as SiNAPSE Institute at the National University of Singapore. Dr. ALL is the director of the Spinal Cord Repair Research Laboratory.

The focus of his research is nervous system injury, repair and regeneration. His laboratory has pioneered the monitoring and quantitative analysis of somatosensory and motor evoked potentials as well as action potentials and compound evoked potentials for assessment of electrical integrity at various stages of pre- and post-peripheral nerve and spinal cord injury. He and his team of researchers are studying plasticity and adaptive changes in the central nervous system, which enable reorganization of spared neuropathways following neuro-trauma. His translational research projects also involve cell replacement therapy using oligodendrocyte precursor cells as well as hypothermia treatment in the contusive model of spinal cord injury. In addition, a part of his laboratory team is also investigating the application of UpConversion Nanoparticles and Optomedicine to specifically depolarize or hyperpolarize neurons deep in neuronal tissues with spatio-temporal precision as well as conjugated nanoparticles to limit the secondary phase of spinal cord injury. He also uses different imaging techniques to monitor anatomical changes in the injured nerves and spinal cord architectures at various time points. These images allow the identification of spared fibers and the tracking of the extent of secondary injury to determine the therapeutic benefits of the various treatment strategies .

Contact:         dosaha@nus.edu.sg (Lab)